Virginia L. Miller

Virginia Miller
At the 2022 Microbe annual meeting
Alma mater
Scientific career
Institutions
ThesisAnalysis of the cholera toxin positive regulatory gene, toxR (1985)

Virginia L. Miller is a microbiologist known for her work on studying the factors leading to disease caused by bacteria. Miller is an elected fellow of the American Academy of Microbiology (2003) and a former Pew Charitable Trust Biomedical Scholar (1989).[1]

Education and career[edit]

Miller has a B.A. from the University of California, Santa Barbara (1979).[2] She earned her Ph.D. from Harvard University in 1985 where she worked on the expression of genes associated with Cholera toxin.[3] Following her Ph.D., she was a postdoc at Stanford University.[4] She moved to the University of California, Los Angeles in 1988 and earned tenure in 1994.[5] She moved to Washington University in St. Louis in 1996, and then to the University of North Carolina at Chapel Hill in 2008.[4] As of 2021, Miller is a professor of genetics, microbiology, and immunology at the University of North Carolina at Chapel Hill.[2]

Research[edit]

Miller is known for her research into bacterial pathogenesis, the factors leading to the onset of disease from specific species of bacteria.[6][7][8][9][10] Her early research examined the synthesis of the cholera toxin by Vibrio cholerae[11][12] and identified environmental signals that lead V. cholerae to express the proteins needed to make the cholera toxin.[13] She went on to examine the mechanisms by which another bacteria pathogen - Yersinia pestis - enters cells[14] and cause disease.[15] She has also worked on how Salmonella[16][17] and Klebsiella pneumoniae[18][19] cause disease.In brief, she mostly worked in the areas of Microbiology (69.74%), Yersinia enterocolitica (51.32%) and Virulence (48.03%).[20]

Awards and honors[edit]

In 1989, Miller was named a Pew Scholar.[1] In 2003, Miller was elected a fellow of the American Academy of Microbiology.[21][5]

Selected publications[edit]

  • Miller, Virginia L.; Taylor, Ronald K.; Mekalanos, John J. (1987-01-30). "Cholera toxin transcriptional activator ToxR is a transmembrane DNA binding protein". Cell. 48 (2): 271–279. doi:10.1016/0092-8674(87)90430-2. ISSN 0092-8674. PMID 3802195. S2CID 28576010.
  • Miller, V L; Mekalanos, J J (1988-06-01). "A novel suicide vector and its use in construction of insertion mutations: osmoregulation of outer membrane proteins and virulence determinants in Vibrio cholerae requires toxR". Journal of Bacteriology. 170 (6): 2575–2583. doi:10.1128/jb.170.6.2575-2583.1988. PMC 211174. PMID 2836362.
  • Taylor, R. K.; Miller, V. L.; Furlong, D. B.; Mekalanos, J. J. (1987-05-01). "Use of phoA gene fusions to identify a pilus colonization factor coordinately regulated with cholera toxin". Proceedings of the National Academy of Sciences. 84 (9): 2833–2837. Bibcode:1987PNAS...84.2833T. doi:10.1073/pnas.84.9.2833. ISSN 0027-8424. PMC 304754. PMID 2883655.

References[edit]

  1. ^ a b "Virginia L. Miller, PhD". PEW Trusts - Biomedical Scholars (1989). Retrieved 2022-03-16.
  2. ^ a b "Virginia Miller, PhD". Institute for Global Health and Infectious Diseases. Retrieved 2021-12-04.
  3. ^ Miller, Virginia L (1985). Analysis of the cholera toxin positive regulatory gene, toxR (Thesis). OCLC 17572198.
  4. ^ a b "Virginia Miller, Ph.D." ASM.org. Retrieved 2021-11-30.
  5. ^ a b "Miller biographical sketch" (PDF). 2014-02-23. Archived (PDF) from the original on 2014-02-23. Retrieved 2021-12-04.
  6. ^ Schmiel, Deborah H.; Miller, Virginia L. (1999-11-01). "Bacterial phospholipases and pathogenesis". Microbes and Infection. 1 (13): 1103–1112. doi:10.1016/S1286-4579(99)00205-1. ISSN 1286-4579. PMID 10572314.
  7. ^ Pepe, J C; Wachtel, M R; Wagar, E; Miller, V L (December 1995). "Pathogenesis of defined invasion mutants of Yersinia enterocolitica in a BALB/c mouse model of infection". Infection and Immunity. 63 (12): 4837–4848. doi:10.1128/iai.63.12.4837-4848.1995. ISSN 0019-9567. PMC 173693. PMID 7591144.
  8. ^ Young, Glenn M.; Miller, Virginia L. (July 1997). "Identification of novel chromosomal loci affecting Yersinia enterocolitica pathogenesis". Molecular Microbiology. 25 (2): 319–328. doi:10.1046/j.1365-2958.1997.4661829.x. PMID 9282744. S2CID 25748196.
  9. ^ Young, G M; Amid, D; Miller, V L (November 1996). "A bifunctional urease enhances survival of pathogenic Yersinia enterocolitica and Morganella morganii at low pH". Journal of Bacteriology. 178 (22): 6487–6495. doi:10.1128/jb.178.22.6487-6495.1996. ISSN 0021-9193. PMC 178535. PMID 8932305.
  10. ^ Weening, Eric H.; Cathelyn, Jason S.; Kaufman, Greer; Lawrenz, Matthew B.; Price, Paul; Goldman, William E.; Miller, Virginia L. (February 2011). Camilli, A. (ed.). "The Dependence of the Yersinia pestis Capsule on Pathogenesis Is Influenced by the Mouse Background". Infection and Immunity. 79 (2): 644–652. doi:10.1128/IAI.00981-10. ISSN 0019-9567. PMC 3028848. PMID 21115720.
  11. ^ Miller, V. L.; Mekalanos, J. J. (1984-06-01). "Synthesis of cholera toxin is positively regulated at the transcriptional level by toxR". Proceedings of the National Academy of Sciences. 81 (11): 3471–3475. Bibcode:1984PNAS...81.3471M. doi:10.1073/pnas.81.11.3471. ISSN 0027-8424. PMC 345530. PMID 6374658.
  12. ^ Miller, Virginia L.; Taylor, Ronald K.; Mekalanos, John J. (1987). "Cholera toxin transcriptional activator ToxR is a transmembrane DNA binding protein". Cell. 48 (2): 271–279. doi:10.1016/0092-8674(87)90430-2. PMID 3802195. S2CID 28576010.
  13. ^ Miller, V L; Mekalanos, J J (1988-06-01). "A novel suicide vector and its use in construction of insertion mutations: osmoregulation of outer membrane proteins and virulence determinants in Vibrio cholerae requires toxR". Journal of Bacteriology. 170 (6): 2575–2583. doi:10.1128/jb.170.6.2575-2583.1988. PMC 211174. PMID 2836362.
  14. ^ Miller, V L; Falkow, S (1988). "Evidence for two genetic loci in Yersinia enterocolitica that can promote invasion of epithelial cells". Infection and Immunity. 56 (5): 1242–1248. doi:10.1128/iai.56.5.1242-1248.1988. ISSN 0019-9567. PMC 259798. PMID 2833444.
  15. ^ Miller, V L; Farmer, J J; Hill, W E; Falkow, S (1989). "The ail locus is found uniquely in Yersinia enterocolitica serotypes commonly associated with disease". Infection and Immunity. 57 (1): 121–131. doi:10.1128/iai.57.1.121-131.1989. ISSN 0019-9567. PMC 313052. PMID 2642465.
  16. ^ Hong, K. Heran; Miller, Virginia L. (1998). "Identification of a Novel Salmonella Invasion Locus Homologous to Shigella ipgDE". Journal of Bacteriology. 180 (7): 1793–1802. doi:10.1128/JB.180.7.1793-1802.1998. ISSN 0021-9193. PMC 107092. PMID 9537377.
  17. ^ Darwin, K. Heran; Miller, Virginia L. (1999). "Molecular Basis of the Interaction of Salmonella with the Intestinal Mucosa". Clinical Microbiology Reviews. 12 (3): 405–428. doi:10.1128/CMR.12.3.405. ISSN 0893-8512. PMC 100246. PMID 10398673.
  18. ^ Lawlor, Matthew S.; Hsu, James; Rick, Paul D.; Miller, Virginia L. (2005). "Identification of Klebsiella pneumoniae virulence determinants using an intranasal infection model: Klebsiella pneumoniae intranasal STM". Molecular Microbiology. 58 (4): 1054–1073. doi:10.1111/j.1365-2958.2005.04918.x. PMID 16262790. S2CID 44666800.
  19. ^ Lawlor, Matthew S.; O'Connor, Christopher; Miller, Virginia L. (2007). "Yersinia bactin Is a Virulence Factor for Klebsiella pneumoniae during Pulmonary Infection". Infection and Immunity. 75 (3): 1463–1472. doi:10.1128/IAI.00372-06. ISSN 0019-9567. PMC 1828572. PMID 17220312.
  20. ^ "Virginia L. Miller: H-index & Awards - Academic Profile". Research.com. Retrieved 2022-07-29.
  21. ^ "American Academy of Microbiology fellows". Retrieved December 3, 2021.
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