CEP170

CEP170
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4JON
Identifiers
Aliases	CEP170, FAM68A, KAB, KIAA0470, centrosomal protein 170
External IDs	OMIM: 613023 MGI: 1918348 HomoloGene: 22844 GeneCards: CEP170
Gene location (Human)
Chr.	Chromosome 1 (human)
End	243,255,348 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	176,641,633 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; corpus callosum; ; sural nerve; ; Achilles tendon; ; cerebellar cortex; ; cerebellar hemisphere; ; stromal cell of endometrium; ; superior frontal gyrus; ; bone marrow; ; prefrontal cortex;
	Top expressed in
	ganglionic eminence; ; hand; ; cumulus cell; ; spermatid; ; neural tube; ; olfactory bulb; ; medial ganglionic eminence; ; cerebellar vermis; ; pineal gland; ; supraoptic nucleus;
	More reference expression data
	n/a
Orthologs
	9859
	545389
	ENSG00000143702; ENSG00000276725
	ENSMUSG00000057335
	Q5SW79
	Q6A065
	NM_001042404; NM_001042405; NM_014812
	NM_001024722; NM_001099637; NM_001368872; NM_001368873
	NP_001035863; NP_001035864; NP_055627
	NP_001093107; NP_001355801; NP_001355802
	Wikidata
View/Edit Human	View/Edit Mouse

Centrosomal protein 170kDa, also known as CEP170, is a protein that in humans is encoded by the CEP170 gene.^[5]^[6]

Function[edit]

The product of this gene is a component of the centrosome, a non-membraneous organelle that functions as the major microtubule organizing center in animal cells. During interphase, the encoded protein localizes to the sub-distal appendages of mature centrioles, which are microtubule-based structures thought to help organize centrosomes. During mitosis, the protein associates with spindle microtubules near the centrosomes. The protein interacts with the intraflagellar transport protein 81 (IFT81), the SH3-domain containing protein PRAX-1, and is phosphorylated by cyclin dependent kinase 1 (Cdk1) and polo-like kinase 1 (PLK1), and functions in maintaining microtubule organization, cell morphology and cilium stability.^[5]

The human genome contains a putative transcribed pseudogene. Several alternatively spliced transcript variants of this gene have been found, but the full-length nature of some of these variants has not been determined.^[5]

References[edit]

^ ^a ^b ^c ENSG00000276725 GRCh38: Ensembl release 89: ENSG00000143702, ENSG00000276725 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000057335 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b ^c "Entrez Gene: CEP170 centrosomal protein 170kDa".
^ Guarguaglini G, Duncan PI, Stierhof YD, Holmström T, Duensing S, Nigg EA (March 2005). "The forkhead-associated domain protein Cep170 interacts with Polo-like kinase 1 and serves as a marker for mature centrioles". Molecular Biology of the Cell. 16 (3): 1095–107. doi:10.1091/mbc.E04-10-0939. PMC 551476. PMID 15616186.

External links[edit]

Human CEP170 genome location and CEP170 gene details page in the UCSC Genome Browser.
PDBe-KB provides an overview of all the structure information available in the PDB for Human Centrosomal protein of 170 kDa (CEP170)

Further reading[edit]

Andersen JS, Wilkinson CJ, Mayor T, et al. (2003). "Proteomic characterization of the human centrosome by protein correlation profiling". Nature. 426 (6966): 570–4. Bibcode:2003Natur.426..570A. doi:10.1038/nature02166. PMID 14654843. S2CID 4427303.
Jin J, Smith FD, Stark C, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol. 14 (16): 1436–50. Bibcode:2004CBio...14.1436J. doi:10.1016/j.cub.2004.07.051. PMID 15324660. S2CID 2371325.
Guarguaglini G, Duncan PI, Stierhof YD, et al. (2005). "The forkhead-associated domain protein Cep170 interacts with Polo-like kinase 1 and serves as a marker for mature centrioles". Mol. Biol. Cell. 16 (3): 1095–107. doi:10.1091/mbc.E04-10-0939. PMC 551476. PMID 15616186.
Kim JE, Tannenbaum SR, White FM (2005). "Global phosphoproteome of HT-29 human colon adenocarcinoma cells". J. Proteome Res. 4 (4): 1339–46. doi:10.1021/pr050048h. PMID 16083285.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
Lamla S (2009). Functional characterisation of the centrosomal protein Cep170. Dissertation, LMU Muenchen: Fakultät für Biologie (Text.PhDThesis). URN nbn:de:bvb:19-97838.

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[refGRCh38Ensembl-1] ENSG00000276725 GRCh38: Ensembl release 89: ENSG00000143702, ENSG00000276725 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000057335 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: CEP170 centrosomal protein 170kDa".

[pmid15616186-6] Guarguaglini G, Duncan PI, Stierhof YD, Holmström T, Duensing S, Nigg EA (March 2005). "The forkhead-associated domain protein Cep170 interacts with Polo-like kinase 1 and serves as a marker for mature centrioles". Molecular Biology of the Cell. 16 (3): 1095–107. doi:10.1091/mbc.E04-10-0939. PMC 551476. PMID 15616186.

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v t e The centrosome and its components
Centrioles	SASS6 CENPJ CNTROB CEP104 Centrins (CETN1, CETN2 and CETN3) SFI1
Pericentriolar material	BBS4 Lck PCM1 PCNT TNKS TNKS2 TUBE1
other proteins	CCP110 CEP55 CEP57 CEP63 CEP68 CEP70 CEP72 CEP76 CEP78 CEP90 CEP97 CEP120 CEP135 CEP152 CEP164 CEP170 CEP192 CEP215 CEP250 CEP350 CNTRL NIN NINL