Werner syndrome ATP-dependent helicase, also known as DNA helicase, RecQ-like type 3, is an enzyme that in humans is encoded by the WRN gene. WRN is a...
29 KB (3,671 words) - 10:42, 9 May 2024
Werner syndrome (WS) or Werner's syndrome, also known as "adult progeria", is a rare, autosomal recessive disorder which is characterized by the appearance...
35 KB (4,271 words) - 07:00, 18 May 2024
Sopher BL, Martin GM, et al. (September 1997). "The Werner syndrome protein is a DNA helicase". Nature Genetics. 17 (1): 100–103. doi:10.1038/ng0997-100...
56 KB (6,919 words) - 16:41, 1 May 2024
DNA helicase family. Mutations in genes encoding other members of this family, namely WRN and RECQL4, are associated with the clinical entities Werner syndrome...
25 KB (2,759 words) - 12:40, 26 March 2024
connected to Werner syndrome. WRN encodes the WRNp protein, a 1432 amino acid protein with a central domain resembling members of the RecQ helicases. WRNp is...
74 KB (8,724 words) - 05:01, 23 March 2024
mutations in the DNA helicase RECQL4 gene, causing problems during initiation of DNA replication has been implicated in the syndrome. Sun-sensitive rash...
10 KB (914 words) - 16:37, 10 May 2024
in RecQ helicases; thus it is crucial that RecQ is present and functional to ensure proper human growth and development. The Werner syndrome ATP-dependent...
17 KB (1,881 words) - 21:26, 18 October 2022
DNA helicases and has both DNA-stimulated ATPase and ATP-dependent DNA helicase activities. Mutations causing Bloom syndrome delete or alter helicase motifs...
24 KB (2,984 words) - 08:31, 25 March 2024
disorder, Werner syndrome". Mutat. Res. 577 (1–2): 252–9. doi:10.1016/j.mrfmmm.2005.03.021. PMID 15916783. Monnat RJ (2010). "Human RECQ helicases: roles...
51 KB (5,554 words) - 14:58, 10 April 2024
disorder, Werner syndrome". Mutat. Res. 577 (1–2): 252–9. doi:10.1016/j.mrfmmm.2005.03.021. PMID 15916783. Monnat RJ (2010). "Human RECQ helicases: roles...
42 KB (3,756 words) - 04:23, 25 March 2024