Two-pore channels (TPCs) are eukaryotic intracellular voltage-gated and ligand gated cation selective ion channels. There are two known paralogs in the...

Ion channels are pore-forming membrane proteins that allow ions to pass through the channel pore. Their functions include establishing a resting membrane...

The two-pore-domain or tandem pore domain potassium channels are a family of 15 members that form what is known as leak channels which possess Goldman-Hodgkin-Katz...

the core of the channel and is functional on its own. When the alpha subunit protein is expressed by a cell, it is able to form a pore in the cell membrane...

the two LBD sections forming a clamshell like shape. Only two of these sites in the tetramer need to be occupied to open the ion channel. The pore is mainly...

Potassium channels are the most widely distributed type of ion channel found in virtually all organisms. They form potassium-selective pores that span...

the core of the channel and is functional on its own. When the alpha subunit protein is expressed by a cell, it is able to form a pore in the cell membrane...

or pH. The CLC family of chloride channels contains 10 or 12 transmembrane helices. Each protein forms a single pore. It has been shown that some members...

such a way that there is a central pore through which ions can travel down their electrochemical gradients. The channels tend to be ion-specific, although...

the voltage sensing domain, the conduction pore, and gating apparatus. Like most voltage-gated ion channels, the α-subunit is composed of 4 subunits. Each...