The thromboxane receptor (TP) also known as the prostanoid TP receptor is a protein that in humans is encoded by the TBXA2R gene, The thromboxane receptor...

asthma. Thromboxane acts by binding to any of the thromboxane receptors, G-protein-coupled receptors coupled to the G protein Gq. Thromboxane is a vasoconstrictor...

increases platelet aggregation. This is achieved by activating the thromboxane receptor, which results in platelet-shape change, inside-out activation of...

a thromboxane synthase inhibitor and as a thromboxane receptor antagonist. The human thromboxane A (TXA) synthase is a 60 kDa cytochrome P450 protein with...

well as regulating the contraction of smooth muscle tissue. Conversely, thromboxanes (produced by platelet cells) are vasoconstrictors and facilitate platelet...

from thromboxane A2 (TXA2) binding (leading to platelet activation and subsequent coagulation). PGI2 also binds to endothelial prostacyclin receptors, and...

dilation of blood vessels stimulating platelet aggregation binds to thromboxane receptor on platelets' cell membranes to trigger platelet migration and adhesion...

PMID 8542839. Lees P, Ewins CP, Taylor JB, Sedgwick AD (1987). "Serum thromboxane in the horse and its inhibition by aspirin, phenylbutazone and flunixin"...

by binding to receptors on airway smooth muscle cells. Bronchoconstrictive leukotrienes act via a common cys-LT1 receptor. Thromboxane is a direct bronchoconstrictor...

Ifetroban is a potent and selective thromboxane receptor antagonist. It has been studied in animal models for the treatment of cancer metastasis, myocardial...