• Thumbnail for Tamoxifen
    Tamoxifen, sold under the brand name Nolvadex among others, is a selective estrogen receptor modulator used to prevent breast cancer in women and men...
    85 KB (8,561 words) - 07:12, 15 January 2024
  • Thumbnail for Selective estrogen receptor modulator
    SERMs are used dependent on their pattern of action in various tissues: Tamoxifen is a first-line hormonal treatment of ER-positive metastatic breast cancer...
    56 KB (6,397 words) - 06:15, 13 January 2024
  • Thumbnail for N-Desmethyltamoxifen
    N-Desmethyltamoxifen (developmental code name ICI-55,548) is a major metabolite of tamoxifen, a selective estrogen receptor modulator (SERM). N-Desmethyltamoxifen...
    4 KB (244 words) - 22:33, 5 March 2022
  • Tamoxifen and Raloxifene (STAR) is a clinical trial from the early 2000s designed determine how the drug raloxifene compares with the drug tamoxifen in...
    3 KB (222 words) - 21:00, 20 December 2023
  • Thumbnail for Etacstil
    receptor-positive breast cancer. It was shown to overcome antiestrogen (tamoxifen, aromatase inhibitor, fulvestrant) resistance in breast cancer by altering...
    8 KB (694 words) - 06:13, 23 February 2024
  • Thumbnail for Exemestane
    positive early breast cancer who have received two to three years of tamoxifen and are switched to it for completion of a total of five consecutive years...
    18 KB (1,764 words) - 00:25, 4 April 2024
  • Thumbnail for Anastrozole
    the treatment and prevention of breast cancer in women. The Arimidex, Tamoxifen, Alone or in Combination (ATAC) trial was of localized breast cancer and...
    27 KB (2,332 words) - 04:27, 27 February 2024
  • Thumbnail for Aromatase inhibitor
    women with breast cancer. Tamoxifen (a SERM) traditionally was the drug treatment of choice, but the ATAC trial (Arimidex, Tamoxifen, Alone or in Combination)...
    21 KB (2,051 words) - 06:17, 13 January 2024
  • Thumbnail for Cre recombinase
    recombinase, resulting in Cre becoming specifically activated by tamoxifen. In the absence of tamoxifen, CreER will result in the shuttling of the mutated recombinase...
    15 KB (1,745 words) - 08:36, 18 January 2024
  • Thumbnail for Endoxifen
    active metabolite of tamoxifen and has been found to be effective in patients that have failed previous hormonal therapies (tamoxifen, aromatase inhibitors...
    15 KB (1,428 words) - 00:43, 9 March 2024