• Thumbnail for TRPM8
    member 8 (TRPM8), also known as the cold and menthol receptor 1 (CMR1), is a protein that in humans is encoded by the TRPM8 gene. The TRPM8 channel is...
    27 KB (3,248 words) - 19:33, 4 January 2024
  • Thumbnail for Thermoreceptor
    has a molecular cousin, TRPM8. Unlike TRPV1, TRPM8 produces cooling sensations as mentioned previously. Similar to TRPV1, TRPM8 responds to a certain chemical...
    10 KB (1,263 words) - 06:25, 2 January 2024
  • Thumbnail for Icilin
    (AG-3-5) is a synthetic super-agonist of the transient receptor potential M8 (TRPM8) ion channel. Although structurally not related to menthol, it produces...
    5 KB (255 words) - 01:39, 2 February 2024
  • Thumbnail for WS-12
    activator of the TRPM8 calcium channel, which is responsible for the sensation of coldness produced by menthol. It is slightly less potent as a TRPM8 activator...
    3 KB (281 words) - 12:45, 5 March 2024
  • Thumbnail for Menthol
    broad needles. Menthol's ability to chemically trigger the cold-sensitive TRPM8 receptors in the skin is responsible for the well-known cooling sensation...
    31 KB (2,865 words) - 10:30, 5 April 2024
  • Thumbnail for David Julius
    pain sensation and heat, including the characterization of the TRPV1 and TRPM8 receptors that detect capsaicin, menthol, and temperature. He is a professor...
    17 KB (1,509 words) - 11:32, 15 April 2024
  • tetramers. The TRPM family consists of eight different channels, TRPM1–TRPM8. Unlike the TRPC and TRPV sub-families, TRPM subunits do not contain N-terminal...
    7 KB (814 words) - 20:35, 20 June 2023
  • Thumbnail for Borneol
    essential oils and it is a natural insect repellent. It also generates a TRPM8-mediated cooling sensation similar to menthol. Laevo-borneol is used in...
    10 KB (744 words) - 01:39, 25 December 2023
  • Thumbnail for Catharanthine
    brain. It is a potent inhibitor of TRPM8, similar to BCTC. Structural analysis of catharanthine shows activity on TRPM8, TRPA1, and butyrylcholinesterase...
    5 KB (353 words) - 04:58, 30 April 2023
  • Thumbnail for Peppermint
    shampoos, soaps, and skin care products. Menthol activates cold-sensitive TRPM8 receptors in the skin and mucosal tissues, and is the primary source of...
    36 KB (3,211 words) - 20:38, 19 March 2024