• Thumbnail for TRPM4
    subfamily M member 4 (hTRPM4), also known as melastatin-4, is a protein that in humans is encoded by the TRPM4 gene. 9-Phenanthrol TRPM4-IN-5 TRPM GRCh38:...
    4 KB (458 words) - 20:54, 20 June 2023
  • Thumbnail for TRPM4-IN-5
    TRPM4-IN-5 is a drug which acts as a moderately potent but highly selective blocker of the TRPM4 ion channel, with an IC50 of 1.5μM. It is protective against...
    2 KB (126 words) - 01:50, 4 February 2024
  • Thumbnail for Excitotoxicity
    that consists of extrasynaptic NMDA receptor and TRPM4. Disruption of this complex using NMDAR/TRPM4 interface inhibitors (also known as ‚interface inhibitors‘)...
    25 KB (2,788 words) - 23:34, 3 December 2023
  • permeability of calcium and magnesium varies widely among TRPM channels. TRPM4 and TRPM5 are impermeable to calcium. TRPM3, TRPM6 and TRPM7 are highly...
    7 KB (814 words) - 20:35, 20 June 2023
  • Thumbnail for Glibenclamide
    2022). "Glibenclamide Directly Prevents Neuroinflammation by Targeting SUR1-TRPM4-Mediated NLRP3 Inflammasome Activation In Microglia". Molecular Neurobiology...
    14 KB (1,066 words) - 06:45, 2 March 2024
  • channel subfamily M member 4 (TRPM4). The NMDAR/TRPM4 complex is considered central to glutamate excitotoxicity. NMDAR/TRPM4 interaction interface inhibitors...
    6 KB (630 words) - 14:34, 22 November 2022
  • Thumbnail for Osmotherapy
    cerebral edema at a molecular level. Targets identified includes: NKCC1, SUR1/ TRPM4 channel, Vasopressin receptor antagonist. During early and reperfusion stage...
    17 KB (2,050 words) - 06:15, 27 December 2023
  • among others. βTRPMs include, but are not limited to, vertebrate TRPM2, TRPM4, TRPM5, and TRPM8 (the cold and menthol sensor). Two additional major clades...
    49 KB (5,514 words) - 11:31, 4 February 2024
  • Thumbnail for Paracetamol
    acid Nicotine (tobacco) Niflumic acid Ononetin PF-05105679 RQ-00203078 Ruthenium red Rutamarin (Ruta graveolens) Tolfenamic acid TPPO TRPM4-IN-5...
    123 KB (12,173 words) - 16:08, 13 May 2024
  • Thumbnail for NMDA receptor
    signaling complex with TRPM4. NMDAR/TRPM4 interaction interface inhibitors (also known as interface inhibitors) disrupt the NMDAR/TRPM4 complex and detoxify...
    107 KB (12,051 words) - 23:49, 26 April 2024