The sigma-2 receptor (σ2R) is a sigma receptor subtype that has attracted attention due to its involvement in diseases such as neurological diseases, neurodegenerative...

siramesine. There are two subtypes, sigma-1 receptors (σ1) and sigma-2 receptors (σ2), which are classified as sigma receptors for their pharmacological similarities...

The sigma-1 receptor (σ1R), one of two sigma receptor subtypes, is a chaperone protein at the endoplasmic reticulum (ER) that modulates calcium signaling...

as the absolute mean value. In biology, the sigma receptor (σ–receptors) is a type of cell surface receptor. In biochemistry, the σ factor (or specificity...

1 nM for the sigma-1 receptor and more than 49 times selectivity over the sigma-2 receptor. Consistent with other reported sigma receptor antagonists,...

protein, the sigma-2 receptor, found in cell membranes. It is highly selective for this over the related sigma-1 receptor. The sigma-2 receptor is significant...

NE-100 or 4-methoxy-3-(2-phenylethoxy)-N,N-dipropylbenzeneethanamine is a selective sigma-1 receptor antagonist, with a reported binding affinity of Ki...

PB-28 is an agonist of the sigma-2 receptor. It is derived from cyclohexylpiperazine. Berardi F, Colabufo NA, Giudice G, Perrone R, Tortorella V, Govoni...

2 ± 1 nM for the sigma-1 receptor and 4 times selectivity over the sigma-2 receptor. Consistent with other reported sigma receptor antagonists, pretreating...

possibly its agonist activity at both the sigma-1 receptor and sigma-2 receptor (the function of these receptors and their clinical relevance has not yet...