Senescence-associated secretory phenotype (SASP) is a phenotype associated with senescent cells wherein those cells secrete high levels of inflammatory...

cell to resume the cell cycle if senescence was initiated by p16Ink4a activation. Senescence-associated secretory phenotype (SASP) gene expression is induced...

it for degradation, it can inhibit GATA-4 associated senescence and senescence-associated secretory phenotype. Mutations in SQSTM1 are a common cause of...

cells influence aging and cancer — in particular the Senescence Associated Secretory Phenotype (SASP). Campisi was born on March 12, 1948. She got her...

symptoms of schizophrenia. IL-6 is commonly found in the senescence-associated secretory phenotype (SASP) factors secreted by senescent cells (a toxic cell-type...

components via autophagy. mTOR is a key initiator of the senescence-associated secretory phenotype (SASP). Interleukin 1 alpha (IL1A) is found on the surface...

inhibitors – agents interfering with pro-inflammatory senescence-associated secretory phenotype (SASP) production, including: Glucocorticoids as potent...

senescent cells, where it contributes to the production of senescence-associated secretory phenotype (SASP) factors. These data suggest that IL-1α is normally...

(2016-09-01). "Keeping the senescence secretome under control: Molecular reins on the senescence-associated secretory phenotype". Experimental Gerontology...

disease risk in aging may be associated with telomere shortening, senescent cells, or SASP (senescence-associated secretory phenotype). Several techniques are...