N6-Methyladenosine (m6A) was originally identified and partially characterised in the 1970s, and is an abundant modification in mRNA and DNA. It is found...
52 KB (5,572 words) - 01:58, 8 April 2024
Epitranscriptome (section N6-Methyladenosine (m6A))
The most common and well-understood mRNA modification at present is N6-Methyladenosine (m6A), which has been observed to occur an average of three times...
61 KB (7,732 words) - 20:34, 13 May 2024
before DNA methylation in the early forms of life evolving on earth. N6-methyladenosine (m6A) is the most common and abundant methylation modification in...
28 KB (3,051 words) - 02:03, 23 April 2024
Nagaraja; Wu, Li (March 2019). "HIV-1 envelope proteins up-regulate N6-methyladenosine levels of cellular RNA independently of viral replication". Journal...
13 KB (1,527 words) - 14:26, 7 May 2024
methylation of internal adenosine residues in eukaryotic mRNAs, forming N6-methyladenosine (m6A). METTL3 forms the m6 a methyltransferase complex with METTL14...
6 KB (752 words) - 18:18, 1 April 2024
gene. It is an RNA-binding protein that acts as a key regulator of N6-Methyladenosine (m6A) methylation of RNAs GRCh38: Ensembl release 89: ENSG00000162775...
5 KB (584 words) - 05:12, 13 August 2023
Guerrero, P Xie, E He, B Shen#, C He#. YTHDC1 mediates nuclear export of N6-methyladenosine methylated mRNAs. elife 2017,6, e31311 H Shi*, X Wang*, Z Lu, B S...
6 KB (594 words) - 22:35, 22 January 2024
3-methyluridine in single-stranded RNA, with low efficiency. The nucleoside N6-methyladenosine (m6A), an abundant modification in RNA, was then found to be a major...
35 KB (3,884 words) - 09:59, 27 March 2024
In enzymology, a mRNA (2'-O-methyladenosine-N6-)-methyltransferase (EC 2.1.1.62) is an enzyme that catalyzes the chemical reaction S-adenosyl-L-methionine...
2 KB (174 words) - 15:00, 26 August 2023
subsequently discovered the first RNA demethylase that oxidatively reverses N6-methyladenosine (m6A) methylation in mammalian messenger RNA (mRNA) in 2011. The existence...
12 KB (1,145 words) - 06:22, 16 February 2024