mTOR inhibitors are a class of drugs used to treat several human diseases, including cancer, autoimmune diseases, and neurodegeneration. They function...

is encoded by the MTOR gene. mTOR is a member of the phosphatidylinositol 3-kinase-related kinase family of protein kinases. mTOR links with other proteins...

The PI3K/AKT/mTOR pathway is an intracellular signaling pathway important in regulating the cell cycle. Therefore, it is directly related to cellular quiescence...

3-kinase inhibitors (PI3K inhibitors) are a class of medical drugs that are mainly used to treat advanced cancers. They function by inhibiting one or more...

rapamycin. These drugs are considered the first generation inhibitors of mTOR. These other inhibitors include everolimus and temsirolimus. Compared with the...

Sirolimus was shown to inhibit the progression of dermal Kaposi's sarcoma in patients with renal transplants. Other mTOR inhibitors, such as temsirolimus...

Immunosuppression BK virus Behcet's Disease Discovery and development of mTOR inhibitors Treatment methods for preventing organ rejection Jennings DL (2020)...

Akt/PKB signaling pathway Discovery and development of mTOR inhibitors PI3K/AKT/mTOR pathway Akt inhibitor PTEN PDB: 3MV5​; Freeman-Cook KD, Autry C, Borzillo...

molecules are called FTIs (or farnesyl-transferase inhibitors). As with mTOR inhibitors, many companies developed them to treat cancers, where they were unsuccessful...

and has also been used to demonstrate a potential application for mTOR inhibitors in the treatment of neuropathic pain. Takeuchi CS, Kim BG, Blazey CM...