Lentiviral vectors in gene therapy is a method by which genes can be inserted, modified, or deleted in organisms using lentiviruses. Lentiviruses are a...

used in clinical and research settings, pioneering lentivirals vector in gene therapy. Jesse Gelsinger's death in 1999 impeded gene therapy research in the...

Gene therapy using lentiviral vectors was being explored in early stage trials as of 2009.[needs update] In a Phase I clinical trial of three patients...

express a specific CAR, using a vector derived from an engineered lentivirus such as HIV (see Lentiviral vector in gene therapy). The CAR programs the T cells...

onset of tumors in a mouse strain prone to tumors. Moreover, clinical trials that utilized lentiviral vectors to deliver gene therapy for the treatment...

(2014). "Long-term safety and tolerability of Pro Savin, a lentiviral vector-based gene therapy for Parkinson's disease: A dose escalation, open-label, phase...

organism. Gene delivery is a necessary step in gene therapy for the introduction or silencing of a gene to promote a therapeutic outcome in patients and...

platelet-factor VIII, the gene that is mutated in human hemophilia. Lentiviral infection has advantages over other gene-therapy methods including high-efficiency...

hosts, and extended gene expression. Lentiviral vectors have also shown promise. Among challenges to clinical translation of gene therapy are possible immune...

Emmanuel (February 2016). "Gene Therapy of the β-Hemoglobinopathies by Lentiviral Transfer of the β – Gene". Human Gene Therapy. 27 (2): 148–165. doi:10...