Inflammasomes are cytosolic multiprotein complexes of the innate immune system responsible for the activation of inflammatory responses and cell death...

is expressed predominantly in macrophages and as a component of the inflammasome,: 436  detects products of damaged cells such as extracellular ATP and...

immune activation and, in the case of inflammasome disorders, are attributable to activation of an inflammasome complex nucleated by innate immune sensors...

autoimmune inflammation Different inflammasome complex — cytosolic molecular complex — have been described. Inflammasomes recognize danger signals and activate...

supramolecular complex termed the inflammasome (also known as a pyroptosome) upon intracellular danger signals. The inflammasome activates a different set of...

pro-caspase-1, to form the inflammasome, a circular structure made of multiple copies of each involved protein. From here, the NLRP3 inflammasome will cleave inactive...

multiprotein complexes called inflammasomes in response to certain infections. In healthy individuals, pyrin-mediated inflammasome assembly (which leads to...

canonical pathway and is activated by canonical inflammasomes such as NLRP3 and NLRC4 inflammasomes, which are multi-protein complexes that are formed...

several factors. Over-activation of the inflammasome is one mechanism contributing to inflammaging. The inflammasome is a multi-protein complex consisting...

leucine-rich repeat and pyrin domain containing receptor 3) inflammasome. An inflammasome can be defined as an immune system receptor that induces inflammation...