INK4 is a family of cyclin-dependent kinase inhibitors (CKIs). The members of this family (p16INK4a, p15INK4b, p18INK4c, p19INK4d) are inhibitors of CDK4...
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two primary CKI families exist: the INK4 family (p16, p15, p18, p19) and the CIP/KIP family (p21, p27, p57). The INK4 family proteins specifically bind...
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many tissues and cell types. The gene codes for two proteins, including the INK4 family member p16 (or p16INK4a) and p14arf. Both act as tumor suppressors...
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isoform '4' encodes p14(ARF), a protein that is structurally unrelated to p16(INK4) but acts in cell cycle G1 control by stabilizing the tumor suppressor protein...
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008. PMC 4536333. PMID 25565328. Xian, T.; Azpurua, J. (27 January 2015). "INK4 locus of the tumor-resistant rodent, the naked mole rat, expresses a functional...
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controlled by the regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. This kinase, as well as CDK4, has been shown to...
35 KB (4,042 words) - 05:00, 1 April 2024
2005, ISBN 978-0-19-926472-8, Section 5.3 Roussel MF (September 1999). "The INK4 family of cell cycle inhibitors in cancer". Oncogene. 18 (38): 5311–5317...
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In 2009, Sharpless and his team were the first to discover altered human INK4/ARF expression as the mechanism for the 9p21.3 genetic risk allele of atherosclerosis...
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centlein CDKN2BAS: CDKN2B antisense RNA 1 or antisense non-coding RNA in the INK4 locus (ANRIL) COL5A1: collagen, type V, alpha 1 DDX31: DEAD box polypeptide...
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Additionally, CDK4/6 and CDK2 are also inactive because CDK4/6 are bound by INK4 family members (e.g., p16), limiting kinase activity. Meanwhile, CDK2 complexes...
77 KB (8,991 words) - 15:41, 30 March 2024