by the FANCD2 gene. The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2 (this gene)...
24 KB (2,488 words) - 21:11, 2 December 2023
E3 ubiquitin-ligase and monoubiquitinates FANCD2 and FANCI. Monoubiquitinated FANCD2, also known as FANCD2-L, then goes on to interact with a BRCA1/BRCA2...
37 KB (4,140 words) - 08:44, 11 April 2024
interact with BRE, BARD1, BCCIP, BRCA1, BRCC3, BUB1B, CREBBP, C11orf30, FANCD2, FANCG, FLNA, HMG20B, P53, PALB2, PCAF, PLK1, RAD51, RPA1, SHFM1 and SMAD3...
72 KB (7,828 words) - 14:11, 16 April 2024
FANCD2/FANCI-associated nuclease 1 (KIAA1018) is an enzyme that in humans is encoded by the FAN1 gene. It is a structure dependent endonuclease. It is...
16 KB (1,817 words) - 20:16, 22 January 2024
ME (September 2009). "The Fanconi anemia protein FANCM is controlled by FANCD2 and the ATR/ATM pathways". The Journal of Biological Chemistry. 284 (38):...
18 KB (1,567 words) - 01:04, 10 March 2024
(FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and...
13 KB (1,363 words) - 21:11, 5 January 2024
(FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, and FANCL. Fanconi anemia is a genetically heterogeneous...
18 KB (2,254 words) - 12:20, 4 January 2024
crosslinks (ICL). A critical step in the pathway is the monoubiquitination of FANCD2 by the RING E3 ligase FANCL. FANCL comprises 3 domains, a RING domain that...
12 KB (1,374 words) - 11:42, 15 January 2024
Thompson LH, Lamerdin JE, Brooks PJ (May 2009). "Acetaldehyde stimulates FANCD2 monoubiquitination, H2AX phosphorylation, and BRCA1 phosphorylation in human...
133 KB (14,899 words) - 23:25, 12 May 2024
FANCD2 protein to the mono-ubiquitinated isoform. In normal, non-mutant, cells FANCD2 is mono-ubiquinated in response to DNA damage. Activated FANCD2...
21 KB (2,456 words) - 00:57, 27 January 2024