is encoded by the MTOR gene. mTOR is a member of the phosphatidylinositol 3-kinase-related kinase family of protein kinases. mTOR links with other proteins...
119 KB (12,654 words) - 16:07, 28 May 2024
mTOR inhibitors are a class of drugs used to treat several human diseases, including cancer, autoimmune diseases, and neurodegeneration. They function...
57 KB (6,276 words) - 20:45, 9 May 2024
MTORC1 (redirect from MTOR Complex 1)
controls protein synthesis. mTOR Complex 1 (mTORC1) is composed of the mTOR protein complex, regulatory-associated protein of mTOR (commonly known as raptor)...
69 KB (7,803 words) - 11:01, 11 April 2024
MTORC2 (redirect from MTOR Complex 2)
mTOR Complex 2 (mTORC2) is an acutely rapamycin-insensitive protein complex formed by serine/threonine kinase mTOR that regulates cell proliferation and...
33 KB (3,678 words) - 23:07, 29 March 2024
The PI3K/AKT/mTOR pathway is an intracellular signaling pathway important in regulating the cell cycle. Therefore, it is directly related to cellular quiescence...
36 KB (4,322 words) - 16:42, 6 October 2023
of cell signaling and cancer metabolism, most notably the co-discovery of mTOR. In 2021 and 2022, Sabatini was fired from the Howard Hughes Medical Institute...
20 KB (1,955 words) - 06:00, 3 May 2024
rejection of kidney transplants. It is a mechanistic target of rapamycin (mTOR) kinase inhibitor that reduces the sensitivity of T cells and B cells to...
68 KB (6,761 words) - 07:28, 29 May 2024
P70-S6 Kinase 1 (section mTOR)
of p70S6K at threonine 389 has been used as a hallmark of activation by mTOR and correlated with autophagy inhibition in various situations. However,...
17 KB (2,127 words) - 02:01, 8 April 2024
the NMDA receptor and downstream effects on regulators such as BDNF and mTOR. It is not clear whether ketamine alone is sufficient for antidepressant...
118 KB (11,403 words) - 06:45, 15 May 2024
genes under investigation in ASD pathophysiology are those that affect the mTOR signaling pathway, which supports cell growth and survival. All these genetic...
241 KB (25,840 words) - 01:52, 29 May 2024