U.S. Route 21 or U.S. Highway 21 (US 21) is a major north–south United States Numbered Highway in the Southeastern United States that extends 394 miles...

U.S. Route 321 (US 321) is a spur of U.S. Route 21. It runs for 516.9 miles (831.9 km) from Hardeeville, South Carolina to Lenoir City, Tennessee; with...

Several special routes of U.S. Route 21 (US 21) exist. In order from south to north, they are as follows. U.S. Highway 21 Business (US 21 Bus.) is a 5.400-mile...

U.S. Route 211 (US 211) is a spur of US 11 in the U.S. state of Virginia. Known for most of its length as Lee Highway, the U.S. Highway runs 59.09 miles...

U.S. Route 421 (also U.S. Highway 421, US 421) is a diagonal northwest–southeast United States Numbered Highway in the states of North Carolina, Tennessee...

U.S. Route 221 (US 221) is a 734-mile-long (1,181 km) spur of U.S. Route 21. It travels from Perry, Florida, at US 19/US 98/US 27 Alternate to Lynchburg...

U.S. Route 66 or U.S. Highway 66 (US 66 or Route 66) was one of the original highways in the United States Numbered Highway System. It was established...

U.S. Route 121 (US 121) is a proposed U.S. highway designated as the Coalfields Expressway, a four-lane highway stretching from Beckley, West Virginia...

U.S. Route 50 or U.S. Highway 50 (US 50) is a major east–west route of the U.S. Highway system, stretching 3,019 miles (4,859 km) from Interstate 80 (I-80)...

U.S. Route 521 (US 521) is a north–south United States Highway that traverses 177.3 miles (285.3 km), from Georgetown, South Carolina, to Charlotte, North...