deacetylase sirtuin-1, is a protein that in humans is encoded by the SIRT1 gene. SIRT1 stands for sirtuin (silent mating type information regulation 2 homolog)...

table below). Mammals possess seven sirtuins (SIRT1–7) that occupy different subcellular compartments: SIRT1, SIRT6 and SIRT7 are predominantly in the nucleus...

cited paper reporting that polyphenols such as resveratrol activate human SIRT1 and extend the lifespan of budding yeast (Howitz et al., Nature, 2003)....

and other protein targets. Elevated SIRT1 levels in people are associated with increased human longevity. SIRT1 (and the other sirtuins) have many metabolic...

focused on resveratrol formulations and derivatives as activators of the SIRT1 enzyme; Sinclair became known for making statements about resveratrol like:...

by which it regulates the activities of antioxidant enzymes through the Sirt1/Foxo3a pathway. Cordycepin has also been evidenced to abate the pathology...

(acetoacetate) in a cultured medium also induced FGF21, possibly via a sirtuin 1 (SIRT1)-dependent mechanism. HMGCS2 activity has also been shown to be increased...

Regulator of SIRT1 Cooperates with SIRT1 and Facilitates Suppression of p53 Activity.” The article describes a nuclear protein and active regulator SIRT1 (AROS)...

youth Immortality in fiction Longevity genes FOXO3 APOE CETP ACE IL6 Klotho SIRT1 TNF Related Blue zone Longevity insurance Longevity risk Transhumanist politics...

complexes that contain DNA methyltransferases (DNMTs), a histone deacetylase (SIRT1), and a histone methyltransferase (EZH2), and thus induce DNA methylation...