Aconitase (aconitate hydratase; EC 4.2.1.3) is an enzyme that catalyses the stereo-specific isomerization of citrate to isocitrate via cis-aconitate in...
15 KB (1,438 words) - 05:10, 6 March 2024
Propane-1,2,3-tricarboxylic acid (category Aconitase inhibitors)
is a tricarboxylic acid. The compound is an inhibitor of the enzyme aconitase and therefore interferes with the Krebs cycle. Esters of propane-1,2,3-tricarboxylic...
3 KB (211 words) - 18:03, 27 February 2024
Aconitase 2, mitochondrial is a protein that in humans is encoded by the ACO2 gene. The secondary structure of ACO2 consists of numerous alternating alpha...
15 KB (1,885 words) - 06:09, 3 June 2024
They have many other functions including catalysis as illustrated by aconitase, generation of radicals as illustrated by SAM-dependent enzymes, and as...
22 KB (2,508 words) - 08:31, 28 January 2024
product. An example of feedback inhibition in human cells is the protein aconitase (an enzyme that catalyses the isomeration of citrate to isocitrate). When...
12 KB (1,677 words) - 14:17, 21 April 2024
the mechanism of aconitase action. Isotope scrambling experiments using tritium, deuterium, and 18O were carried out on the aconitase hydratase reaction...
29 KB (3,878 words) - 21:36, 25 November 2023
to an inhibition of the enzyme aconitase (EC 4.2.1.3) by high concentrations of reactive oxygen species (ROS) Aconitase catalyzes the conversion of citrate...
14 KB (1,487 words) - 20:19, 6 April 2024
inactivates the citric acid cycle enzyme aconitase, can poison energy metabolism, and releases potentially toxic iron. Aconitase is one of several iron-sulfur-containing...
47 KB (5,042 words) - 11:47, 21 April 2024
to isocitrate in the citric acid cycle. It is acted upon by the enzyme aconitase. Aconitic acid can be synthesized by dehydration of citric acid using...
5 KB (237 words) - 15:39, 23 May 2024
or degradation. It functions also as the cytoplasmic isoform of aconitase. Aconitases are iron-sulfur proteins that require a 4Fe-4S cluster for their...
8 KB (997 words) - 02:27, 18 October 2022