Proto-oncogene vav is a protein that in humans is encoded by the VAV1 gene. The protein encoded by this proto-oncogene is a member of the Dbl family of...
17 KB (1,999 words) - 06:15, 25 December 2023
it can activate the membrane-bound Ras. Other GEFs, such as the Rho GEF Vav1, are activated upon phosphorylation in response to upstream signals. Secondary...
18 KB (2,253 words) - 09:08, 21 October 2023
STAT5A; STAT5B; STAT6 SUPT6H; SYK TEC; TENC1; TNS; TNS1; TNS3; TNS4; TXK VAV1; VAV2; VAV3 YES1; ZAP70 Phosphotyrosine-binding domains also bind phosphorylated...
13 KB (1,341 words) - 04:09, 6 March 2024
Phosphorylated LAT recruits SLP-76 to the membrane, where it can then bring in PLC-γ, VAV1, Itk and potentially PI3K. PLC-γ cleaves PI(4,5)P2 on the inner leaflet of...
71 KB (9,026 words) - 12:33, 26 April 2024
with: AHNAK, IMPA1, IQGAP1, MAPT, and P53, PGM1, S100A1, S100A6, S100A11, VAV1. GRCh38: Ensembl release 89: ENSG00000160307 – Ensembl, May 2017 GRCm38:...
19 KB (2,387 words) - 05:56, 12 April 2024
towards bound pathogens or cells. In humans there are three Vav proteins: Vav1 Vav2 Vav3 Bustelo, X. R. (March 2000). "Regulatory and Signaling Properties...
2 KB (186 words) - 13:35, 27 June 2022
after the ligand binding by recruiting the p85 subunit of PI3K and Grb2-Vav1 complex which are responsible for subsequent downstream events. In mice,...
31 KB (3,695 words) - 20:24, 13 October 2022
PTPN11 PTPN6 PRMT5 SH2B1 SHC1 SOCS3 STAT5A STAT5B STAM SOCS1 TEC TNFRSF1A VAV1 YES1 Prolactin signals through JAK2 are dependent on STAT5, and on the RUSH...
28 KB (3,166 words) - 03:42, 4 January 2024
VAV2 gene. VAV2 is the second member of the VAV oncogene family. Unlike VAV1, which is expressed exclusively in hematopoietic cells, VAV2 transcripts...
10 KB (1,204 words) - 03:24, 24 May 2024
RAPGEF1, RET proto-oncogene, SH2B1, SH3KBP1, SHC1, SOS1, Src, Syk, TNK2, TrkA, VAV1, VAV2, VAV3, and Wiskott-Aldrich syndrome protein. MAPK/ERK pathway GRCh38:...
82 KB (9,365 words) - 15:39, 31 March 2024