serine/threonine-specific protein kinase that, in humans, is encoded by the CHEK1 gene. Chk1 coordinates the DNA damage response (DDR) and cell cycle checkpoint...
30 KB (3,340 words) - 01:47, 26 March 2024
is a small molecule checkpoint kinase inhibitor, mainly active against CHEK1, with minor activity against CHEK2. This causes induction of DNA double-strand...
3 KB (107 words) - 11:55, 2 August 2023
Checkpoint kinase may refer to: CHEK1, a protein kinase that is encoded by the CHEK1 gene CHEK2, a tumor suppressor gene that encodes the CHK2 kinase This...
394 bytes (58 words) - 02:25, 18 July 2018
recombination in human and mouse, CHEK1 protein kinase is important for integrating DNA damage repair with cell cycle arrest. CHEK1 is expressed in the testes...
26 KB (3,047 words) - 02:53, 3 December 2023
Mir-15 microRNA precursor family (section CHEK1)
at an important role of miR-15/16 in normal CD5+ B-cell homeostasis. The CHEK1 (checkpoint kinase 1) gene, located at chromosome position 11q24.2, is responsible...
10 KB (1,246 words) - 10:47, 10 September 2021
CAMK1B CAMK1D CAMK1G CAMK2 CAMK2A CAMK2B CAMK2D CAMK2G CAMK4 MLCK CASK CHEK1 CHEK2 DAPK1 DAPK2 DAPK3 STK11 MAPKAPK2 MAPKAPK3 MAPKAPK5 MARK1 MARK2 MARK3...
3 KB (303 words) - 14:35, 26 August 2023
mediating class switch recombination. Phosphorylation of Cdc25C by CDS1 and CHEK1 creates a binding site for the 14-3-3 family of phosphoserine binding proteins...
12 KB (1,318 words) - 14:27, 10 March 2024
CAMK1B CAMK1D CAMK1G CAMK2 CAMK2A CAMK2B CAMK2D CAMK2G CAMK4 MLCK CASK CHEK1 CHEK2 DAPK1 DAPK2 DAPK3 STK11 MAPKAPK2 MAPKAPK3 MAPKAPK5 MARK1 MARK2 MARK3...
46 KB (5,509 words) - 06:42, 23 May 2024
CAMK1B CAMK1D CAMK1G CAMK2 CAMK2A CAMK2B CAMK2D CAMK2G CAMK4 MLCK CASK CHEK1 CHEK2 DAPK1 DAPK2 DAPK3 STK11 MAPKAPK2 MAPKAPK3 MAPKAPK5 MARK1 MARK2 MARK3...
69 KB (7,803 words) - 11:01, 11 April 2024
CAMK1B CAMK1D CAMK1G CAMK2 CAMK2A CAMK2B CAMK2D CAMK2G CAMK4 MLCK CASK CHEK1 CHEK2 DAPK1 DAPK2 DAPK3 STK11 MAPKAPK2 MAPKAPK3 MAPKAPK5 MARK1 MARK2 MARK3...
45 KB (4,671 words) - 07:44, 19 May 2024