(AN2) or oculorhombin, is a protein that in humans is encoded by the PAX6 gene. PAX6 is a member of the Pax gene family which is responsible for carrying...

ataxia). The AN2 region of the short arm of chromosome 11 (11p13) includes the PAX6 gene (named for its PAired boX status), whose gene product helps regulate...

factors include the genes EMX2 and PAX6. Together, both transcription factors form an opposing gradient of expression. Pax6 is highly expressed at the rostral...

master control gene PAX6, a homeobox gene with known homologues in humans (aniridia), mice (small eye), and Drosophila (eyeless). The PAX6 gene locus is a...

due to independent variants of Pax6 arising in both cephalopods and vertebrates. Cephalopods contain five variants of Pax6 in their genomes which independently...

the PAX6 ocular development gene and the Wilms' tumour gene (WT1). Abnormalities in WT1 may also cause genitourinary anomalies. Mutations in the PAX6 gene...

proven, it is thought that SHH emitted from the prechordal plate suppresses Pax6, which causes the eye field to divide into two. If the SHH gene is mutated...

and usually a partial, or in the case of four family members (PAX3, PAX4, PAX6 and PAX7), a complete homeodomain to the C-terminus. An octapeptide as well...

some may be highly counter-intuitive. For example, deep homologies like the pax6 genes that control the development of the eyes of vertebrates and arthropods...

control differentiation along major body axes, and pax genes (especially PAX6) help to control the development of the eye and other sensory organs. The...