DNA repair is a collection of processes by which a cell identifies and corrects damage to the DNA molecules that encode its genome. In human cells, both...
128 KB (15,713 words) - 00:20, 25 May 2024
DNA mismatch repair (MMR) is a system for recognizing and repairing erroneous insertion, deletion, and mis-incorporation of bases that can arise during...
35 KB (4,179 words) - 16:38, 9 May 2024
Neoplasm (section DNA damage)
defective in DNA mismatch repair or in homologous recombinational repair (HRR). During repair of DNA double strand breaks, or repair of other DNA damages,...
51 KB (5,873 words) - 20:06, 7 June 2024
shown that deficient DNA repair, allowing greater accumulation of DNA damage, causes premature aging; and that increased DNA repair facilitates greater...
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Base excision repair (BER) is a cellular mechanism, studied in the fields of biochemistry and genetics, that repairs damaged DNA throughout the cell cycle...
29 KB (3,489 words) - 15:28, 28 February 2024
Cell damage (section DNA damage and repair)
can remove DNA damages (see chart in DNA repair). However, those DNA damages that remain un-repaired can have detrimental consequences. DNA damages may...
23 KB (2,829 words) - 04:04, 16 January 2024
DSB repair mechanisms: Homologous recombination (HR) and non-homologous end joining (NHEJ). HR relies on undamaged template DNA as reference to repair the...
34 KB (4,127 words) - 22:54, 30 March 2024
to the damage. DNA damage and mutation have different biological consequences. While most DNA damages can undergo DNA repair, such repair is not 100% efficient...
79 KB (9,956 words) - 11:19, 14 March 2024
Cancer epigenetics (section MicroRNA and DNA repair)
cell-cycle inhibitor; MGMT, a DNA repair gene; APC, a cell cycle regulator; MLH1, a DNA-repair gene; and BRCA1, another DNA-repair gene. Indeed, cancer cells...
111 KB (12,530 words) - 17:53, 14 April 2024
MLH1 (section Role in DNA mismatch repair)
DNA mismatch repair protein Mlh1 or MutL protein homolog 1 is a protein that in humans is encoded by the MLH1 gene located on chromosome 3. The gene is...
28 KB (3,414 words) - 10:03, 27 March 2024